Spectroscopy of Biopolymers           Syllabus for 2007 autumn semester

Web:      http://www.cyut.edu.tw/~wjchien      

 

Instructor:      Wei-Jyun Chien (錢偉鈞); Applied Chemistry, CYUT

Tel: 23323000 ext. 7230 or 4307,   e-mail: wjchien@mail.cyut.edu.tw

Lecture:         Wednesday 14:00~17:00

Textbooks:

1.        Physical Chemistry 1st ed.; Thomas Engel and Philip Reid; Pearson Education, Inc.

2.        Instrumental Analysis 4th ed.; Skoog and Leary; Fort Worth :/Saunders College Pub.

3.        Principles of Fluorescence Spectroscopy 2nd ed. J. R. Lakowicz, Kluwer Academic / Plenum Publisher. 1999

4.        Circular dichroism : principles and applications 2nd ed. edited by Nina Berova, Koji Nakanishi, Robert W. Woody.  Wiley-VCH , c2000

5.        NMR of Proteins and Nucleic Acids Kurt Wüthrich, Wiley International Publication. 1986.

6.        Infrared and Raman Spectroscopy, Methods and Applications, edited by Bernhard Schrader, VCH, 1995.

7.       Infrared Spectral Interoretation, A Systematic Approach Brian Smith, CRC Press, 1999.

e-books:

1.      Protein Structure and Function  by Gregory Petsko and Dagmar Ringe, New Science Press Ltd, 2004. http://www.new-science-press.com/browse/protein

2.       Protein Structure Determination in Solution by Two-Dimensional and Three-Dimensional Nuclear Magnetic Resonance Spectroscopy Angela M. Gronenborn* and G. Marius Clore* 2Anal. Chem. 1990, 62, 2-15.    http://pubs.acs.org/cgi-bin/archive.cgi/ancham/1990/62/i01/pdf/ac00200a003.pdf  

Schedule:

Contents

Slides

Reading

9/16

17

18

19

20

21

22

Introduction – Webs and tools

S1-1

 

23

24

25

26

27

28

29

Introduction to Biopolymers I – peptides and proteins

S2-1,S2-2

 

30

10/1

2

3

4

5

6

Introduction to Biopolymers II – nucleic acids and hydrocarbons

S2-3, S2-4

 

7

8

9

10

11

12

13

Holiday

 

 

14

15

16

17

18

19

20

Introduction to Spectroscopy I -Vibrational & Rotational Spectroscopy

S3

 

21

22

23

24

25

26

27

Applications of IR Spectroscopy on Biopolymers I

 

 

28

29

30

31

11/1

2

3

Applications of IR Spectroscopy on Biopolymers II

 

 

4

5

6

7

8

9

10

Introduction to Spectroscopy II - Electronic Spectroscopy

 

 

11

12

13

14

15

16

17

Applications of UV-Vis Spectroscopy

 

 

18

19

20

21

22

23

24

Applications of Fluorescence Spectroscopy on Biopolymers I

 

 

25

26

27

28

29

30

1

Applications of Fluorescence Spectroscopy on Biopolymers II
 
 

2

3

4

5

6

7

8

Introduction to Spectroscopy III – Circular Dichroism Spectroscopy

 

 

9

10

11

12

13

14

15

Applications of CD Spectroscopy on Biopolymers I

 

 

16

17

18

19

20

21

22

Applications of CD Spectroscopy on Biopolymers II

 

 

23

24

25

26

27

28

29

Introduction to Spectroscopy IV – NMR Spectroscopy

 

 

30

31

1

2

3

4

5

NMR Spectroscopy and Protein Conformational Study

 

 

6

7

8

9

10

11

12

NMR Spectroscopy and Protein Conformational Study

 

 

13

14

15

16

17

18

19

Final Exam